We translate leading edge science into medical applications

About Us

Our Mission
MT-act is a preclinical stage spin-off company, stemming from the Institute of Human Genetics (Montpellier, France), a joint research institute under governance of the French National Centre for Scientific Research (CNRS) and the University of Montpellier (UM).

We develop class compounds to treat human pathologies that share a common molecular defect; dysfunction of the microtubular network. Microtubules are the largest cytoskeletal elements and provide structural support to human cells in addition to accommodating the intracellular trafficking system employed to deliver essential cargoes. Numerous human pathologies have specifically been linked to dysregulation of microtubule properties and this is where we act.

The company roots on a unique platform technology providing chemical versatility to develop first-in-class compounds that serve drug development programs. Employing a knowledge-based view, MT-act develops drug candidates to correct microtubule dysfunctions. The choice of the targeted mode of action is highly differentiated.

Origin and Innovation
MT-act is established on leading edge scientific research and capitalises on the discoveries of doctor Krzysztof Rogowski, an outstanding scientist who contributed to the identification of over 20 microtubule modifying enzymes during his career.

Based on breakthrough discoveries, proprietary technologies and unique expertise, MT-act screens, validates and isolates the best compounds with a unique microtubule-focused mode-of-action (MoA). MT-act pre-clinically develops compounds to act and restore microtubule function (MT).

Solution

Unique approach and new mechanism of action (MoA). Proprietary biochemical assay for compound screening.

Research

First-in-class compounds that target a microtubule-focused mechanism of action (MoA).

Unmet medical need

Glaucoma is an eye disease notorious as the world’s leading cause of irreversible blindness. Affecting 20 million people in Europe and the US.

Experience

Trained and experienced team of biochemists, molecular and cellular biologists.

Our Partners

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